Edgar Ramirez was born in San Cristóbal, Venezuela on March 25th 1977. Before he dedicated himself full time into acting, he was the executive director for the campaign Dale al Voto, which was sponsored by ONG. Later on in 2004, Édgar Ramírez jumped into fame when he interpreted the character Cacique in the telenovela Costa Rica. Around the same time, he also participated in the movies Yotama se va Volando and Punto y Raya. After debuting in the Venezuelan cinema, Édgar Ramírez landed an opportunity to co-star the American movie Domino.

Later on in 2007, Édgar participated in the movie El Ultimátum de Bourne along with Matt Damon. Here he interpreted Paz, an assassin. The following year he partook in the film Vintage Point along with Dennis Quaid, Forest Whitaker, Matthew Fox, and Eduardo Noriega to name a few. Then in 2010, he starred the film Carlos, where he interpreted a well-known terrorist from his country. His performance was so good that he got nominated in the Golden Globe Awards. His most recent work has been in the film Libertador.